Plant Transcription Factor Database
Previous version: v3.0
Pyrus bretschneideri
M-type_MADS Family
Species TF ID Description
Pbr001328.1M-type_MADS family protein
Pbr001458.1M-type_MADS family protein
Pbr001460.1M-type_MADS family protein
Pbr001551.1M-type_MADS family protein
Pbr003216.1M-type_MADS family protein
Pbr004239.1M-type_MADS family protein
Pbr004263.1M-type_MADS family protein
Pbr005989.1M-type_MADS family protein
Pbr005990.1M-type_MADS family protein
Pbr005991.1M-type_MADS family protein
Pbr006693.1M-type_MADS family protein
Pbr006794.1M-type_MADS family protein
Pbr006795.1M-type_MADS family protein
Pbr006798.1M-type_MADS family protein
Pbr006809.1M-type_MADS family protein
Pbr007029.1M-type_MADS family protein
Pbr007292.1M-type_MADS family protein
Pbr007481.1M-type_MADS family protein
Pbr007915.1M-type_MADS family protein
Pbr008076.1M-type_MADS family protein
Pbr008912.1M-type_MADS family protein
Pbr009640.1M-type_MADS family protein
Pbr010321.1M-type_MADS family protein
Pbr011423.3M-type_MADS family protein
Pbr016601.1M-type_MADS family protein
Pbr018829.1M-type_MADS family protein
Pbr019318.1M-type_MADS family protein
Pbr019339.1M-type_MADS family protein
Pbr020186.1M-type_MADS family protein
Pbr022012.1M-type_MADS family protein
Pbr022183.1M-type_MADS family protein
Pbr022939.1M-type_MADS family protein
Pbr025656.1M-type_MADS family protein
Pbr025657.1M-type_MADS family protein
Pbr025970.1M-type_MADS family protein
Pbr025981.1M-type_MADS family protein
Pbr026073.1M-type_MADS family protein
Pbr026074.1M-type_MADS family protein
Pbr026075.1M-type_MADS family protein
Pbr026551.1M-type_MADS family protein
Pbr027548.1M-type_MADS family protein
Pbr029054.1M-type_MADS family protein
Pbr029333.1M-type_MADS family protein
Pbr030435.1M-type_MADS family protein
Pbr031262.1M-type_MADS family protein
Pbr031473.1M-type_MADS family protein
Pbr032195.1M-type_MADS family protein
Pbr033409.1M-type_MADS family protein
Pbr033418.1M-type_MADS family protein
Pbr034610.1M-type_MADS family protein
Pbr036758.1M-type_MADS family protein
Pbr036986.1M-type_MADS family protein
Pbr036992.1M-type_MADS family protein
Pbr037101.1M-type_MADS family protein
Pbr039074.1M-type_MADS family protein
Pbr039561.1M-type_MADS family protein
Pbr039562.1M-type_MADS family protein
Pbr039897.1M-type_MADS family protein
Pbr039900.1M-type_MADS family protein
Pbr040108.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513